Many orthopaedic disorders can be treated with limb-sparing procedures. However, there are certain problems, such as aggressive malignant bone and soft-tissue tumors with neurovascular involvement or widespread contamination of soft tissues, severe trauma with limited remaining vital structures, musculoskeletal sequelae of vascular disease, or chronic infections that are recalcitrant to surgical and medical management, and which are sometimes best managed with amputation. Amputation can provide an appropriate solution to eradicate the disease process, and with prosthetic fitting and rehabilitation can result in satisfactory function and quality of life. The level of amputation determines the energy expenditure necessary to ambulate; however, individuals with the desire to return to an active life often have little or no limitation to activity. Advances in prosthetic design have made it possible for amputation patients to walk, run, and play sports. This technique guide summarizes the procedural steps and surrounding knowledge required for performing an above-knee amputation.Quick Tips