A clinical practice guideline (CPG) is a compilation of procedure recommendations for a particular disease topic that are supported by the best available literature on the disease topic under study. High quality evidence-based CPGs employ a systematic literature review in which the quality of supporting studies is assessed and potential biases are addressed and minimized. This module outlines the role of AAOS CPGs, as well as their structure and the 9 phases of the AAOS development process.